Using ribosome engineering (RE), researchers from Shinshu University introduced mutations affecting the protein synthesis ...

Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for ...

Researchers at VIB and KU Leuven have identified a molecular process that allows motor neurons to maintain protein production ...

New modeling shows how synonymous mutations -- those that change the DNA sequence of a gene but not the sequence of the encoded protein -- can still impact protein production and function. New ...

Researchers at VIB and KU Leuven have identified a molecular process that allows motor neurons to maintain protein production, a process that fails in amyotrophic lateral sclerosis (ALS).

Studying the role of mitochondria—the specialized structures within cells responsible for energy production—in metabolic diseases has been difficult because of a lack of animal models with the ...

Researchers have developed the first mouse model for a mitochondrial tRNALeu mutation, showing that the associated metabolic disorder results from faulty RNA processing. Studying the role of ...

Scientists have discovered an additional potential cause of the genetic mutations that result in rare conditions such as Huntington’s disease (HD). The neurodegenerative diseases, which also include ...