We examined how remote enhancers establish physical communication with target promoters to activate gene transcription in response to environmental signals. Although the natural IFN-β enhancer is ...
When the molecular machinery in our cells gets to work transcribing the genetic information encoded in DNA into messenger RNA (mRNA), it pauses shortly after starting. Known as promoter-proximal ...
Transcription promoter elements, like history, may not repeat themselves, but they often rhyme. Consider the Initiator (Inr) element, a core promoter that initiates transcription and regulates the ...
Efficient Bacterial Transcription of DNA Nanocircle Vectors with Optimized Single-Stranded Promoters
We describe experiments aimed at establishing whether circular single-stranded DNAs can form promoters for bacterial transcription from small folded motifs. In vitro selection experiments were carried ...
Humans have it. So does Drosophila. But not yeast. That "it" is a small pause at the start of gene activity—a brief molecular ...
Transcription is the first step of gene expression, where a DNA sequence is copied into messenger RNA. In eukaryotes, transcription initiation starts with the assembly of the transcription ...
Scientists at Penn State University will reveal in the 29 March 2007 issue of the journal Nature the first complete high-resolution map of important structures that control how genes are packaged and ...
Designers of cancer drugs have begun to aim their arrows at an up-and-coming series of targets in the human genome: quadruplexes, a family of DNA structures that form in sites that switch genes on ...
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