New mutations in TP53 gene drive resistance to p53-targeted cancer therapy

Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for ...

Scientists report new immune insights and targets into LRRK2 mutations in Parkinson's disease

Parkinson's disease (PD) is a debilitating and progressive neurodegenerative disorder caused by the loss of ...

Adolore BioTherapeutics Announces FDA Orphan Drug Designation for its Kv7-activating rdHSV-CA8* Therapy in the Treatment of Erythromelalgia

Orphan Drug Designation applies to approximately 50,000 Patients who predominantly suffer from severe chronic pain due to ...

Phages and bacteria accumulate distinctive mutations aboard the International Space Station

In a new study, terrestrial bacteria-infecting viruses were still able to infect their E. coli hosts in near-weightless ...

Scientists identify pre-cancerous states in seemingly normal aging tissues

A new single-cell profiling technique has mapped pre-malignant gene mutations and their effects in solid tissues for the ...
Nature

The infection enigma: why some people die from typically harmless germs

Among the most famous demonstrations of genetic mutations driving infection outcome is severe combined immunodeficiency (SCID ...

New method reveals how mutations drive transthyretin amyloidosis and guides precision drug design

An international research team reveals new molecular mechanisms associated with pathogenic mutations in the protein ...
Newsweek

Men’s Harmful Sperm Mutations Increase With Age—Study Reveals Hidden Cause

While men may be able to have children much later than women, doing so could come with an increased risk of inherited disease for their children. Researchers from the Wellcome Sanger Institute have ...

Compressed data technique enables pangenomics at scale

Engineers at the University of California have developed a new data structure and compression technique that enables the ...