Researchers at the University of Minnesota Medical School have developed a new method called PARTAGE that provides a clearer picture of how the genome is regulated and disrupted in diseases like ...

A cancer drug target already being investigated in clinical trials turns out to be doing something even more consequential ...

Researchers at The University of Texas MD Anderson Cancer Center have identified an epigenetic target for replication stress, ...

DNA replication is a fundamental process essential for bacterial growth and survival. Initiation begins at the chromosomal origin (oriC), where the conserved initiator protein DnaA assembles into an ...

Scientists reveal a hidden second layer of human DNA, showing how genome folding controls genes and influences disease development.

Researchers discovered a kinase-driven phosphorylation switch that activates DNA packaging machinery, aligning nucleosomes at ...

The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must ...

Scientists used a bacterial system called retron to turn DNA into a programmable tool inside living cells, enabling gene ...

The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...

A study conducted in fruit flies by investigators at the University of Alabama at Birmingham has linked a patient variant of ...

Before a cell can divide, it has to precisely duplicate its entire genetic information. However, the DNA in the cell exists as part of a DNA-protein complex known as chromatin. For this purpose, the ...