Machine learning models reveal that histone marks are predictive of gene expression across human cell types and highlight important nuances between natural control and the effects of CRISPR-Cas9-based ...

Northwestern Medicine scientists have discovered how molecular "traffic controllers" in cells influence aging and cellular senescence—a state where cells stop dividing but remain metabolically active.

The code base for our work on improving the performance of sequence-to-expression models for making individual-specific gene expression predictions by fine-tuning them on personal genome and ...

All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics—meticulously placed chemical tags that influence which genes are expressed in ...

Different variants of a gene, known as isoforms, can be transcribed and translated at varying levels within a cell or tissue. These isoforms are commonly a result of alternative splicing, which ...

Wheat is the most widely cultivated crop in the world; over 215 million hectares are grown annually. To meet the demands of a growing global population, plant breeders face the challenge of increasing ...

Using genomic and transcriptional data has greatly improved the understanding of multiple aspects of human physiology. A new paper in PNAS reports on molecular-level associations of co-occurring ...

The 22-gene Decipher genomic classifier (GC) (22-gene GC) is the only gene expression test with National Comprehensive Cancer Network (NCCN) level 1 evidence for localized prostate cancer (PCa) ...

Precision Treatment of Patients With GI Cancer Using Pre-emptive DPYD Genotyping/Phenotyping Plus Pharmacokinetic-Guided Dosing of 5-Fluorouracil Primary PCa biopsy samples underwent ...

(A) Selected human single-cell transcriptome profiles from HCL and other public datasets were utilized to train and validate gPRINT. The human single-cell data encompasses 159,302 cells from 26 ...