Catechol-O-methyltransferase - Wikipedia
Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines (neurotransmitters such as dopamine, epinephrine, and norepinephrine), …
Normal Function The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. Two versions of this enzyme are made from the gene. The longer form, called …
What Is a COMT Mutation and How Does It Affect Your Health?
Jul 27, 2025 · The COMT enzyme is responsible for breaking down catecholamines, which include neurotransmitters like dopamine, norepinephrine, and epinephrine. This process, known as …
What Is the COMT Gene? And How Does It Affect Your Health?
Nov 4, 2025 · Because of the effects that COMT has on hormones, it directly affects stress reactivity, health, and well-being. Interestingly, those with this gene appear to experience both negative and...
Do You Have COMT Gene Mutation, COMT Symptoms & Testing
Catechol-O-methyltransferase (COMT) or COMT enzyme activity is important to the areas of the pre-frontal cortex, this area of the brain is involved with personality, inhibition of behaviours, short-term …
The COMT Mutation: How It Impacts Stress and Strategies for Coping
A COMT mutation has a huge effect on how your body responds to stress. Here’s how it affects you and steps you can take to lead a healthier life.
1312 - Gene ResultCOMT catechol-O-methyltransferase [ (human)]
In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. …
COMT Gene Mutations: Symptoms, Test, and Treatment
Oct 29, 2024 · COMT mutations disrupt the breakdown of neurotransmitters, especially dopamine, resulting in mood swings, anxiety, and cognitive difficulties. You can test for COMT mutations …
Entry - *116790 - CATECHOL-O-METHYLTRANSFERASE; COMT
In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. …
COMT Gene: Neurotransmitter Levels, Estrogen Metabolism, and SNPs
Jan 8, 2020 · The COMT gene controls the breakdown of neurotransmitters such as dopamine. Check your genetic raw data to see if you carry the COMT variants.